04. HIPEC [Hyperthermic Intraperitoneal Chemotherapy]:
The patients who are suffering from advanced stage ovarian cancer or recurrent ovarian cancer undergo a complete cytoreductive surgery by which the entire visible disease is resected. In other words, optimal cytoreductive surgery is performed. At the end of the surgery, the temperature of the abdomen is raised to 41 to 43 degrees Celsius by insufflation of warm fluid, and the abdominal cavity is then treated with the infusion of chemotherapy agents like cisplatin for over one and a half hour.
There is a recent evidence in the form of multicentric trial to support this treatment modality. This type of cytoreductive surgery – which is combined with HIPEC, increases the life span of the patient, the disease-free interval, and this can be achieved without unduly affecting the overall morbidity and mortality associated with the procedure.